Viral Meningitis & Encephalitis

Early diagnosis of meningitis and encephalitis saves lives.

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Meningitis and encephalitis are inflammatory conditions of the central nervous system (CNS) that can lead to high rates of mortality and disability worldwide.

Meningitis is the inflammation of the meninges, the membranes that surround the brain and spinal cord.
Encephalitis is the inflammation of the brain itself.

Meningitis and encephalitis can occur as a result of certain viral, bacterial, fungal, and parasitic infections.

Herpes simplex virus types 1 and 2 are common causes of viral meningitis and encephalitis. While herpes simplex meningitis is a self-limiting condition in patients with normal immunity1, herpes simplex encephalitis (HSE) is a life-threatening disease and it requires prompt treatment with intravenous antivirals.

Anyone at any age can get HSE. Although HSE is rare, mortality rate can reach 70% in the absence of therapy and only a minority of individuals return to normal function2. Intravenous acyclovir has shown to reduce mortality to 10-20%3. A rapid diagnosis is then critical to successful patient outcome.

1. Logan SAE, MacMahon E. Viral meningitis. BMJ. 2008;336(7634):36-40. doi:10.1136/bmj.39409.673657.AE
2. Tyler KL. Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret’s. Herpes. 2004;11 Suppl 2:57A-64A.
3. Whitley RJ. Herpes Simplex Virus Infections of the Central Nervous System. Continuum (Minneap Minn). 2015;21(6 Neuroinfectious Disease):1704-1713. doi:10.1212/CON.0000000000000243

Annual impact of Meningitis in the United States


Meningitis-related hospitalizations


0.4 to 11.4% in-hospital mortality rate


$1.2 billion
Healthcare cost

Annual impact of Encephalitis in the United States


Encephalitis-related hospitalizations


5.8 to 17.1% in-hospital mortality rate


$2 billion
Healthcare cost

Our Solution


Our proposed solution will deliver fast and accurate results in less than 30 minutes.

Although large meningitis and encephalitis molecular panels can identify a wide variety of CNS infection pathologies, studies are showing that they have moderate sensitivity for some targets and that additional testing is required for suspected HSE when results are negative4,5, resulting in a delay in diagnosis.
For professional use.
The miDiagnosticsTM HSV-1&2 CSF Test is intended to detect HSV-1 and HSV-2 targets with a high sensitivity, reducing the need for further confirmatory testing.
4. Vaugon E, Mircescu A, Caya C, et al. Diagnostic accuracy of rapid one-step PCR assays for detection of herpes simplex virus-1 and -2 in cerebrospinal fluid: a systematic review and meta-analysis. Clin Microbiol Infect. 2022;28(12):1547-1557. doi:10.1016/j.cmi.2022.06.004
5. Dien Bard J, Alby K. Point-Counterpoint: Meningitis/Encephalitis Syndromic Testing in the Clinical Laboratory. J Clin Microbiol. 2018;56(4):e00018-18. doi:10.1128/JCM.00018-18
How it works

How it works.

With sample preparation, amplification and detection, turnaround time is less than 30 minutes.


200 µl of Cerebrospinal fluid (CSF) is mixed with the PCR reagents.

PCR Card

A small volume of the sample (5µl) is placed on the disposable PCR Card containing the silicon chip.


The multiple use, portable reader performs the temperature cycling and optical detection, processes data and communicates the test result.

Key Benefits.


Unique silicon chip technology allowing for ultra-fast PCR


Built-in controls ensure the highest quality result


<12 minutes for real-time PCR


Closed reaction chamber limits risk of contamination


High clinical performance


Platform compatible with various tests


If you are interested in further information as we get closer to launching our miDiagnosticsTM HSV-1&2 CSF Test please contact