PRODUCTS

Viral Meningitis & Encephalitis

Early diagnosis of meningitis and encephalitis saves lives.

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Background

Meningitis and encephalitis are inflammatory conditions of the central nervous system (CNS) that can lead to high rates of mortality and disability worldwide.

Meningitis is the inflammation of the meninges, the membranes that surround the brain and spinal cord.
Encephalitis is the inflammation of the brain itself.

Meningitis and encephalitis can occur as a result of certain viral, bacterial, fungal, and parasitic infections.

Herpes simplex virus types 1 and 2 are common causes of viral meningitis and encephalitis. While herpes simplex meningitis is a self-limiting condition in patients with normal immunity1, herpes simplex encephalitis (HSE) is a life-threatening disease and it requires prompt treatment with intravenous antivirals.

Anyone at any age can get HSE. Although HSE is rare, mortality rate can reach 70% in the absence of therapy and only a minority of individuals return to normal function2. Intravenous acyclovir has shown to reduce mortality to 10-20%3. A rapid diagnosis is then critical to successful patient outcome.

1. Logan SAE, MacMahon E. Viral meningitis. BMJ. 2008;336(7634):36-40. doi:10.1136/bmj.39409.673657.AE
2. Tyler KL. Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret’s. Herpes. 2004;11 Suppl 2:57A-64A.
3. Whitley RJ. Herpes Simplex Virus Infections of the Central Nervous System. Continuum (Minneap Minn). 2015;21(6 Neuroinfectious Disease):1704-1713. doi:10.1212/CON.0000000000000243

Annual impact of Meningitis in the United States

>
0

Meningitis-related hospitalizations

0
%

0.4 to 11.4% in-hospital mortality rate

$
0
b

$1.2 billion
Healthcare cost

Annual impact of Encephalitis in the United States

>
0

Encephalitis-related hospitalizations

0
%

5.8 to 17.1% in-hospital mortality rate

$
0
b

$2 billion
Healthcare cost

Our Solution

Ultra-fast.
Ultra-reliable.

Our proposed solution will deliver fast and accurate results in less than 30 minutes.

Although large meningitis and encephalitis molecular panels can identify a wide variety of CNS infection pathologies, studies are showing that they have moderate sensitivity for some targets and that additional testing is required for suspected HSE when results are negative4,5, resulting in a delay in diagnosis.
For professional use.
The miDiagnosticsTM HSV-1&2 CSF Test (coming soon) is intended to detect HSV-1 and HSV-2 targets with a high sensitivity, reducing the need for further confirmatory testing.
4. Vaugon E, Mircescu A, Caya C, et al. Diagnostic accuracy of rapid one-step PCR assays for detection of herpes simplex virus-1 and -2 in cerebrospinal fluid: a systematic review and meta-analysis. Clin Microbiol Infect. 2022;28(12):1547-1557. doi:10.1016/j.cmi.2022.06.004
5. Dien Bard J, Alby K. Point-Counterpoint: Meningitis/Encephalitis Syndromic Testing in the Clinical Laboratory. J Clin Microbiol. 2018;56(4):e00018-18. doi:10.1128/JCM.00018-18
How it works

How it works.

With sample preparation, amplification and detection, turnaround time is less than 30 minutes.

Sample

200 µl of Cerebrospinal fluid (CSF) is mixed with the PCR reagents.

PCR Card 2.0

A small volume of the sample is placed on the disposable PCR Card containing the silicon chip.

Reader 2.0

The multiple use, portable reader performs the temperature cycling and optical detection and is connected to a computer.

Computer

The computer with intuitive User Interface and integrated software enables complete sample to answer traceability with easy to interpret results in a data secure manner.

Key Benefits.

Innovation

Unique silicon chip technology allowing for ultra-fast PCR

Quality

Built-in controls ensure the highest quality result

Speed

<12 minutes for real-time PCR

Safety

Closed reaction chamber limits risk of contamination

Performance

High clinical performance

Versatility

Platform compatible with various tests

Interested?

If you are interested in further information as we get closer to launching our miDiagnosticsTM HSV-1&2 CSF Test please contact info@midiagnostics.com

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